Epix (Gen 2).
I have had issue with low heart rate at beginning of the activity. It started intermittently with Software v15.77. It got worse with v16.22. I did testing before and was able to replicate and resolve the issue, by toggling the headphones on/off. Another fix is to pause activity, reboot device, and resume activity. These are just temporary fixes.
I just updated to v17.23 this week. My first 2 runs had normal HR. I thought maybe Garmin fixed the issue, or the update reset some setting that resolved the issue. Unfortunately, that was short lived. Issue returned on my 3rd run. So I did headphone toggling test again. No surprise. Same result.
Here is comparison between Epix on top graph versus Vivoactive 4 at bottom graph, for the identical run. By toggling the headphone status between on and off, I can cause Epix to have low HR reading.