SDK: 7.4.3 (this actually looks to be a bug in every SDK which contains the sample, starting with 3.1.8 and ending with 8.0.0-beta)
manifest.xml in the NordicyThingy52.xml contains fr645 as a supported product, but it shouldn't.
If the NordicThingy52 sample is built for fr645 and run on the sim, the app will crash with a Symbol Not Found error the first time the BluetoothLowEnergy module is accessed.
Note that the fr645m product *does* support ble.