I think this may have been discussed before, but on iOS at least, the CIQ app settings will sometimes exit automatically, silently discarding all changes. This is especially a problem if the user modified a lot of settings.
This happens when the watch syncs over bluetooth, either automatically or manually initiated through the controls menu.
Unfortunately you need to be connected over bluetooth to modify settings through the app, so it seems to me the only workaround is to manually sync before you change settings, so the next automatic sync will hopefully come much later.