1) Regular CBR 320-encoded mp3 files (from lossless) - sound is breaking up quite often while on Run activity (running).
Bose QuietComfort 35 headphones.
Nothing else in my hands while running, no iPhone etc. that could be trying to connect with the headphones.
2) A loud sound like "microphone backfeeding" is cutting through the music when the voice announces each lap stats.
Update:
Did a run wearing Apple Airpods Pro (1st Gen) - not a single issue.
I guess it's the compatibility of Bose QuietComfort 35 with the Epix Pro.