Shifters sometimes not responsive

Sometime my shifters do not response as they should. Riding on a flat coarse in a movie of the tacx training app the shifters respond instantly either going up or down. However when I go downhill in the lowest gear and reach the end of the descent and I want to quickly shift up the shifter do not respond. On the display of the bike I see that it changes the gear but the bike it self doesn't shift at all or there is a delay of 1 to 2 seconds. Does anyone experience this same behavior.