Unit set up - general

How does a misaligned unit set up affect the stats? In this instance I am thinking of how important it is to have the unit perfectly level? I assume it will affect launch and direction more than club and ball speed?

If a unit is out of alignment (including level) could this impact spin number calculations? (Which for reference appear to be VERY inconsistent, which is why I am asking. I'd like to set the unit up to optimize spin, path and club face stats to try and remove the variability)