Dug out the box and in the Quick Start Manual I tried Resetting the Device and that fixed my problem. Just hold the power button for at least 10 seconds.
Unit was in the car dock when it displayed a couple of low battery warnings even though the dock was connected via the cigar lighter and the red power light was on. A few times it displayed the unlock pin page even though it was still giving audio directions. When I turned onto a different freeway, part of the route marker and the road itself disappeared.
I decided to cycle power and after I selected OFF, game over. Could not get the Nuvi to power on with the power button, returning it to the car docking station, or connecting it to my computer.