upload failure edge 305

That makes two of us.
Screen hangs at the 'reading activities please wait' stage, however there is an error warning on the IE page listed below.
Webpage error details

User Agent: Mozilla/4.0 (compatible; MSIE 8.0; Windows NT 6.0; Trident/4.0; GTB6; SLCC1; .NET CLR 2.0.50727; Media Center PC 5.0; .NET CLR 3.5.30729; .NET CLR 3.0.30729)
Timestamp: Wed, 19 Aug 2009 09:49:10 UTC


Message: <?xml version="1.0" encoding="UTF-8" standalone="no" ?>
<ErrorReport xmlns="www.garmin.com/.../v1">

<Error>
<Exception>
<SubId>6</SubId>
<SourceCodeLocation>
<SourceFileName>IOU_USBLINKIMPL.CPP</SourceFileName>
<SourceFileLine>754</SourceFileLine>
</SourceCodeLocation>
<Extra>Windows Error Code: 6
The handle is invalid.
</Extra>
</Exception>
<Application>
<Name>Garmin Communicator Plug-In</Name>
<Build>
<Version>
<VersionMajor>2</VersionMajor>
<VersionMinor>7</VersionMinor>
<BuildMajor>1</BuildMajor>
<BuildMinor>0</BuildMinor>
</Version>
<Type>Internal</Type>
<Time>May 7 2009, 10:50:27</Time>
<Builder>sqa</Builder>
</Build>
<LanguageID>1033</LanguageID>
<PartNumber>006-A0160-00</PartNumber>
</Application>
<Computer>
<OperatingSystem>Windows Vista Service Pack 2</OperatingSystem>
<Processor>x86, Processor Level: 6, Processors:2, Model: 15 Stepping: 13</Processor>
<RamSize>3134780</RamSize>
</Computer>
<Time>2009-08-19T09:48:38Z</Time>
</Error>

</ErrorReport>

Line: 386
Char: 3
Code: 0
URI: http://connect.garmin.com/resource/communicator-api/2.3-SNAPSHOT/garmin/device/GarminDevicePlugin.js

Any ideas?