How did you install it? Apparently problems have been resolved by selecting Run rather than saving the .exe file to your PC, others have reported success saving the .exe file then selecting 'Run as administrator' ... try whichever one you haven't.
The latest version of Garmin Express is 3.2.13. Please download and install it from the link below. If you use Internet Explorer choose the RUN option rather than Saving it to the computer first.