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Garmin Express won't launch on Windows 10 20H2

New Dell desktop with Windows 10 20H2. First tried the Aug 30, 2021 version of Garmin Express installer that we have successfully used on a Windows 10 20H laptop. This version installed without a problem but would not run. Then uninstalled and downloaded the latest Oct 5 2021 version and that also installs fine. This too will not  run despite trying to run as administrator, Windows 8 and 7 compatible and changing permission.

Both this new computer and the laptop Garmin Express works on have Norton 360 and other similar applications. Any idea what would prevent the program from launching?

Connecting my Garmin 2589 GPS via USB before trying to launch did not work.

Thanks.