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Garmin Express / Windows

Haven't used my Garmin Nuvi for a while but was updating some files on my PC which is up to date so thought I'd update that at the same time.

I can launch Garmin Express. I keep getting the following error message :  . Even when I manually find the .exe file and try and run it I still get the same message.  I've unistallled, reinstalled on multiple occasions but nothing seems to work.  I've followed a few solutions on the forum but again keep getting the same message.  Even downloaded a software unistaller to try and clear all remnants of Garmin Express  Contacted Garmin support who were't really supportive and suggested that its a PC fault so need a new PC especially as I managed to get it to work on my daughters laptop but that's only a temporary solution as it should work on the PC. 

Any thoughts / solutions welcome :)